The main Dow Jones index was down almost 250 points, or 1.4%, at 16,964 in morning trading.
Investor confidence was also knocked by weak durable goods orders figures released by the Commerce Department.
European markets also fell sharply after Wall Street opened.
Germany’s Dax and France’s Cac 40 indexes were down about 1.5%, while the UK’s FTSE 100 was 1.2% lower.
Other technology stocks listed on Wall Street were also hit by Apple’s slide – both Microsoft and Intel were down 1.6%.
Earlier, the world’s biggest technology company apologised after an update to iOS 8.0.1 left some iPhone users unable to make or receive calls.
The company is also under fire following claims that its new iPhone 6 Plus had bent while in users’ pockets.
Analysts suggested Apple would soon overcome these issues and its shares would soon recover.
“Apple’s decline is due to a confluence of unforced errors such as the botched iOS 8 update but, with the stock holding up well following the recent product announcements, today’s declines could be more of a dip that offers a buying opportunity rather than the start of a bigger slump,” said Chris Beauchamp, market analyst at IG.
Meanwhile, the Commerce Department said durable goods orders had fallen more than 18% in August from July, to $245bn. However, the drop was largely expected and followed a sharp increase in July, largely due to a jump in orders at airplane maker Boeing.
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